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This paper scrutinizes the nonlinear multibubble model with considering bubble-bubble (BB) interaction in Cu?Al2O3/water hybrid nanofluid over vapour bubble radius Newtonian mediums. Firstly, we present derivation of extended Rayleigh-Plesset (ERP) equation under effect BB nanofluids based on Navier-Stokes equation. The is formulated by continuity equation, ERP and relations thermophysical features mono nanofluids. transformed into an ordinary differential using non-dimensions variables methodology, which then solved analytically modified Plesset-Zwick method. In addition, current presents influence interactions growth process Cu?Al2O3/H2O As a result, impact increasing number bubbles “n” nanofluid, at n=1,2,3 are investigated. Moreover, it found that dynamics increases when distance between volume concentration decrease. less than cases water-base fluid Al2O3/water Additionally, radii study give good agreement lower behavior if compared prior investigations.